effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: a pilot study

background: repeated implantation failure (rif) is a major challenge in reproductive medicine and despite several methods that have been described for management, there is little consensus on the most effective one. objective: this study was conducted to evaluate the effectiveness of platelet-rich plasma in improvement of pregnancy rate in rif patients. materials and methods: twenty women with a history of rif who were candidates for frozen-thawed embryo transfer were recruited in this study. intrauterine infusion of 0.5 ml of platelet-rich plasma that contained platelet 4-5 times more than peripheral blood sample was performed 48 hrs before blastocyst transfer. results: eighteen participants were pregnant with one early miscarriage and one molar pregnancy. sixteen clinical pregnancies were recorded and their pregnancies are ongoing. conclusion: according to this study, it seems that platelet-rich plasma is effective in improvement of pregnancy outcome in rif patients